Most profitable US companies
Innoviva, Inc. (INVA) ranks first among 286 US stocks Fisclear covers, with net margin of 65.9%, ahead of Micron Technology, Inc. at 63.8%.
Data as of 14 October 2026. Rankings update automatically as company reports refresh.
| # | Company | Net margin |
|---|---|---|
| 1 | Innoviva, Inc.INVA | 65.9% |
| 2 | Micron Technology, Inc.MU | 63.8% |
| 3 | AppLovin CorporationAPP | 60.8% |
| 4 | Nvidia CorpNVDA | 55.6% |
| 5 | Winmark CorporationWINA | 48.4% |
| 6 | Microsoft CorporationMSFT | 40.3% |
| 7 | PTC Therapeutics, Inc.PTCT | 39.4% |
| 8 | Novavax IncNVAX | 39.2% |
| 9 | Palantir Technologies Inc.PLTR | 36.3% |
| 10 | Broadcom Inc.AVGO | 36.2% |
| 11 | KLA CorporationKLAC | 35.6% |
| 12 | Credo Technology Group Holding LtdCRDO | 35.4% |
| 13 | Vertex Pharmaceuticals IncVRTX | 32.9% |
| 14 | Alphabet Inc.GOOGL | 32.8% |
| 15 | Marvell Technology, IncMRVL | 32.6% |
| 16 | Mcdonald’s CorporationMCD | 31.9% |
| 17 | Copart, Inc.CPRT | 31.8% |
| 18 | ELI Lilly And CompanyLLY | 31.7% |
| 19 | TransMedics Group, Inc.TMDX | 31.4% |
| 20 | Regeneron Pharmaceuticals, Inc.REGN | 31.4% |
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How this list is built
Net margin: net profit as a share of revenue in the latest fiscal year. Real estate and financial companies are left out because property revaluation gains and lending income make their margins incomparable with other businesses. Margins outside −100% to 100% are excluded as unreliable.
It ranks the 286 US stocks in Fisclear's coverage with reliable data for this measure, not every listed company. Reports that fail our data sanity checks are left out. See the methodology. This is information, not investment advice.